Spectral Entropy & Entropy Similarity

By considering an MS/MS spectrum as a probability distribution, we introduced the concept of Spectral Entropy to evaluate the information within the spectrum. Expanding on this idea, we proposed Entropy Similarity as a metric to measure the similarity between two spectra. Utilizing this approach can lead to a reduction in the false positive rate for metabolite identification by up to 40%. A video introduction to Spectral Entropy and Entropy Similarity can be found here.