Projects
Flash Entropy Search is an ultra-fast algorithm capable of comparing billions of MS/MS spectra in seconds, and boosting the speed of library searches by five orders of magnitude. This method enables rapid comparison of MS/MS spectra against large spectral libraries, just like BLAST for sequence searches. A video introduction to Flash Entropy Search can be found here.
By considering an MS/MS spectrum as a probability distribution, we introduced the concept of Spectral Entropy to evaluate the information within the spectrum. Expanding on this idea, we proposed Entropy Similarity as a metric to measure the similarity between two spectra. Utilizing this approach can lead to a reduction in the false positive rate for metabolite identification by up to 40%. A video introduction to Spectral Entropy and Entropy Similarity can be found here.
